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KMID : 1161420130160090785
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Journal of Medicinal Food
2013 Volume.16 No. 9 p.785 ~ p.792
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Rubus coreanus Miquel Inhibits Acetylcholinesterase Activity and Prevents Cognitive Impairment in a Mouse Model of Dementia
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Kim Cho-Rong
Choi Soo-Jung
Oh Seung-Sang
Kwon Yoon-Kyung
Lee Na-Young
Park Gwi-Gun
Kim Youn-Jung
Heo Ho-Jin
Jun Woo-Jin
Park Cheung-Seog
Shin Dong-Hoon
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Abstract
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To find acetylcholinesterase (AChE) inhibitors for the prevention of neurological disorders, such as Alzheimer's disease, ethanol extracts of promising traditional edible Korean plants were tested. Among them, Rubus coreanus Miquel extract exhibited the most significant AChE inhibitory activity. The effect of R. coreanus extract on trimethyltin-induced memory impairment in mice was investigated using Y-maze and passive avoidance tests. Our results showed that administration of R. coreanus extract significantly improved alternation behavior and step-through latency. In addition, R. coreanus extract was sequentially fractionated, and the purified constituent was determined to be 3,4,5-trihydroxybenzoic acid.
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KEYWORD
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acetylcholine, acetylcholinesterase inhibitor, alzheimer's disease, Rubus coreanus Miquel
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